The medicinal effect of Nerium indicum in wound healing
DOI:
https://doi.org/10.31305/rrijm.2026.v11.n04.011Keywords:
oleander, Nerium indicum, wound management, modern medicineAbstract
Nerium indicum (commonly known as oleander) is a medicinal plant traditionally used in various herbal systems for treating skin disorders and wounds. This study aims to evaluate the wound-healing potential of Nerium indicum through its phytochemical constituents and pharmacological properties. The plant contains bioactive compounds such as flavonoids, tannins, alkaloids, and glycosides, which are known for their antimicrobial, anti-inflammatory, and antioxidant activities. These compounds contribute to accelerating the wound-healing process by reducing microbial infection, promoting collagen synthesis, and enhancing tissue regeneration. Experimental observations indicate that extracts of Nerium indicum may improve wound contraction, epithelialization, and overall healing rate. The findings suggest that Nerium indicum has significant therapeutic potential as a natural agent for wound management. However, further clinical studies and toxicity evaluations are necessary to ensure its safe and effective application in modern medicine.
References
[1] Adhimoolam, K., Do Thi, C. T., Chin, S., Sureshbabu, A., Smirnova, E., Mohammad, M., ... & Kim, I. J. (2025). Turmeric (Curcuma longa L.): the multifaceted golden plant—insights and uses. Plant Biotechnology Reports, 19(6), 593-625.
[2] Alberts, A., Tudorache, D. I., Niculescu, A. G., & Grumezescu, A. M. (2025). Advancements in wound dressing materials: Highlighting recent progress in hydrogels, foams, and antimicrobial dressings. Gels, 11(2), 123.
[3] Ashalatha, B. (2025). Exploring the Role of Medicinal Plants in Ayurveda: A Comprehensive Review. Medicinal plants and Their uses: Basic to Field, 122.
[4] Balkrishna, A., Srivastava, D., Sharma, N., Parveen, R., Kukreti, A., & Arya, V. (2025). Global Trends in the Integration of Traditional and Modern Medicine: Challenges and Opportunities. Future Integrative Medicine, 4(4), 217-232.
[5] Bhandari, D. D., Hatkar, K. S., Rathod, S. P., Kachave, R. R., Amrutkar, S. V., & Shinkar, D. M. (2025). Exploring Herbal Remedies: Traditional Wisdom Meets Modern Science. Herbal Nanotherapy for Diabetes, 52-83.
[6] Deng, X., Ratnayake, J., & Ali, A. (2025). Curcumin-loaded drug delivery systems for acute and chronic wound management: a review. Bioengineering, 12(8), 860.
[7] El-Saadony, M. T., Saad, A. M., Mohammed, D. M., Alkafaas, S. S., Ghosh, S., Negm, S. H., ... & El-Tarabily, K. A. (2025). Curcumin, an active component of turmeric: biological activities, nutritional aspects, immunological, bioavailability, and human health benefits-a comprehensive review. Frontiers in immunology, 16, 1603018.
[8] Haesler, E., Swanson, T., Ousey, K., Sussman, G., Larsen, D., Weir, D., ... & Waters, N. (2025). Therapeutic wound and skin cleansing: clinical evidence and recommendations.
[9] Hanafiah, O. A., Abidin, T., Ilyas, S., Nainggolan, M., & Syamsudin, E. (2019). Wound healing activity of binahong (Anredera cordifolia (Ten.) Steenis) leaves extract towards NIH-3T3 fibroblast cells. Journal of International Dental and Medical Research, 12(3), 854-858.
[10] Haralović, V., Mokos, M., Špoljar, S., Dolački, L., Šitum, M., & Lugović-Mihić, L. (2025). Hypochlorous acid: clinical insights and experience in dermatology, surgery, dentistry, ophthalmology, rhinology, and other specialties. Biomedicines, 13(12), 2921.
[11] Jung, S. M., Kim, H. I., Kim, S. Y., Jang, S. J., Seo, H. H., Lee, J. H., ... & Moh, S. H. (2025). Production of Aloe vera Phytoplacenta Extract and Potential Applications in Skincare. Life, 15(3), 397.
[12] Kotian, S. R., Padma, D., Madhukar, R., & Bhat, K. M. (2017). Effect of natural medicines on dermal fibroblasts in wound healing: an in-vitro study. Advanced Science Letters, 23(3), 1949-1956.
[13] Kumar, B., Misra, A., & Srivastava, S. (2025). Bioavailability of Nutri-Ayur Products: Innovations in Ayurvedic Nutrition. In Innovations in Ayurvedic Nutrition: Translational Research and Applications (pp. 225-238). Singapore: Springer Nature Singapore.
[14] Kumar, D., Pandey, S., Shiekmydeen, J., Kumar, M., Chopra, S., & Bhatia, A. (2025). Therapeutic potential of microneedle assisted drug delivery for wound healing: current state of the art, challenges, and future perspective. AAPS PharmSciTech, 26(1), 25.
[15] Mail, I. D. (2025). Ayurveda’s Approach Towards Preventing Lifestyle Disorders and Maintaining Social Health.
[16] Najar, I. A., Pamu, S., Patyar, S., Madhira, G., Sharma, A., Devi, S. & Kumar, M. (2025). Stress Management Therapy through Adaptogens and Rasayanas in Ayurveda: A Comprehensive Review. Current Drug Therapy, 20(4), 564-580.
[17] Patil, A. (2025). Evaluating The Efficacy Of Ayurvedic Dietary Interventions In Reducing Inflammation And Amavata (Rheumatoid Arthritis) Symptoms: A Comprehensive Review. American Journal of Psychiatric Rehabilitation, 28(1), 631-639.
[18] Razavi, Z. S., Aliniay Sharafshadehi, S., Yousefi, M. H., Javaheri, F., Rahimi Barghani, M. R., Afkhami, H., & Heidari, F. (2025). Application of novel strategies in chronic wound management with focusing on pressure ulcers: new perspective. Archives of Dermatological Research, 317(1), 320.
[19] Shinde, R. V., Deshmukh, S., Varma, A., Kate, S., Thakre, T., & Shelke, S. (2025). Immunity and Ayurvedic Rasayana Drugs in Children: A Comprehensive Review. Journal of Pharmacy and Bioallied Sciences, 17( 3), S2119-S2122.
[20] Sikka, M. P., Bargir, J. A., & Garg, S. (2025). Modern developments in burn wound dressing. Research Journal of Textile and Apparel, 29(3), 487-506.
[21] Yadav, R., Tiwari, N., Nainwal, L. M., Hasan, N., Kumar, N., & Kumar, V. (2025). Exploring Commercially Available Formulations for Efficient Wound Healing: A Review. International Journal of Environmental Sciences, 11(19s), 2025.
[22] Yamamoto, K. (2025). Revisiting the Etiology and Management of Atopic Dermatitis: A Perspective on Skin Microbiota, Bathing Habits, and Surfactant-Free Skincare. Clinical, Cosmetic and Investigational Dermatology, 1087-1093.
